Ovatoxin-a

FULL PAPER DOI: 10.1002/chem.201201357 Stereochemical Studies on Ovatoxin-a Patrizia Ciminiello, Carmela Dell Aversano, Emma Dello Iacovo, Ernesto Fattorusso†, Martino Forino,* Laura Grauso, and Luciana Tartaglione[a] In memory of Ernesto Fattorusso Abstract: Ovatoxin-a is the main toxin toxin: in comparison with palytoxin, the 42-position.

Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak P Ciminiello, C Dell’Aversano, E Fattorusso, M Forino, L Tartaglione, 42-hydroxypalytoxin, ostreocin-d, ovatoxin-a, -b,-c,-d, -e and -f and mascarenotoxin-a, -b and -c. However only the chemical structures of PLTX, ostreocin-d, ovatoxin-a and 42-hydroxypalytoxin have been characterized [4-11]. PLTX is a large molecule, with a molecular weight of 2659-2680 daltons depending on the origin [12,13]. Nov 24, 2008 · Two of the most remarkable properties of palytoxin are the large and complex structure (with different analogs, such as ostreocin‐D or ovatoxin‐a) and the extreme acute animal toxicity. The Na + /K + ‐ATPase has been proposed as receptor for palytoxin. Apr 04, 2011 · Ciminiello P, Dell'Aversano C, Fatturosso E, Forino M, Tartaglione L, et al.

21.06.2021 Ovatoxin-a

Geoditin A, an isomalabaricane triterpene isolated from marine sponge Geodia japonica, has been demonstrated to induce apoptosis in leukemia HL60 cells and human colon HT29 cancer cells through an oxidative stress, a process also interfering with normal melanogenesis in pigment cells. Treatment of murine melanoma B16 cells with geoditin A decreased expression of melanogenic proteins and cell 1009813-91-5 - RZASWFCAHPACCD-FAXBYDSISA-N - Ovatoxin A - Similar structures search, synonyms, formulas, resource links, and other chemical information. Dinoflagellates of the genus Ostreopsis are known to cause (often fatal) food poisoning in tropical coastal areas following the accumulation of palytoxin (PLTX) and/or its analogues (PLTX group) in crabs, sea urchins or fish. Abstract Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and This study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (PLTX) analog, ovatoxin-a (OVTX-a), the major toxin produced by Ostreopsis cf.

1009813-91-5 - RZASWFCAHPACCD-FAXBYDSISA-N - Ovatoxin A - Similar structures search, synonyms, formulas, resource links, and other chemical information.

Ostreopsis cf. ovata; palytoxin A Biblioteca Virtual em Saúde é uma colecao de fontes de informacao científica e técnica em saúde organizada e armazenada em formato eletrônico nos países da Região Latino-Americana e do Caribe, acessíveis de forma universal na Internet de modo compatível com as bases internacionais. Ovatoxin A | C129H223N3O52 | CID 90479618 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities OVTX-a is about 100 fold less potent than PLTX in reducing HaCaT cells viability (EC 50 = 1.1 × 10 –9 M vs 1.8 × 10 –11 M, MTT test) in agreement with a reduced binding affinity (Kd = 1.2 × 10 –9 vs 2.7 × 10 –11 M, saturation experiments on intact cells). Feb 17, 2012 · The ovatoxin was quantified using the PLTX standard.

P. Ciminiello, C. Dell'Aversano, E. Fattorusso et al., “Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the ligurian coasts during the 2006 toxic outbreak,” Journal of the American Society for Mass Spectrometry, vol. 19, no. 1, pp. 111–120, 2008. View at: Publisher Site | Google Scholar

2006 (Ciminiello et al. , 2008 Guerrini et al Availability of pure ovatoxin-a will open the double prospect of fully evaluating its toxicity and preparing reference standards to be employed in LC/MS quantitative analyses. Elucidation of ovatoxin-a’s complex structure will ultimately herald the understanding of the molecular bases of ovatoxins bioactivity.

Abstract Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and Availability of pure ovatoxin-a will open the double prospect of fully evaluating its toxicity and preparing reference standards to be employed in LC/MS quantitative analyses. Elucidation of ovatoxin-a's complex structure will ultimately herald the understanding of the molecular bases of ovatoxins bioactivity. Ovatoxin‐a has recently been isolated from cultures of O. ovata and structurally identified as an analogue of palytoxin: in comparison with palytoxin, ovatoxin‐a lacks three hydroxy groups at the 17‐, 44‐ and 64‐positions, but features an extra hydroxy functionality at the 42‐position. Herein we report on the NMR‐based elucidation Fragmentation pattern of palytoxin was used as template to gain detailed structural information on ovatoxin-a, the main toxin produced by Ostreopsis ovata, (observe correct font) a benthic dinoflagellate that currently represents the major harmful algal bloom threat in the Mediterranean area. Sep 21, 2013 · Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and environmental suffering.

Sep 21, 2013 · Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and environmental suffering. Ovatoxin‐a has recently been isolated from cultures of O. ovata and structurally identified as an analogue of palytoxin: in comparison with palytoxin, ovatoxin‐a lacks three most cases ovatoxin-a was the only toxin detected (83 % of samples), and the remaining 17 % of samples contained it in association with ovatoxin-d/e. Alerted by the repeated occurrence of palytoxin-producing species in the Mediterranean, the European Food Safety Authority (EFSA), in its statement on the areas. At least 8 different PlTX analogues are known: PlTX, ostreocin-D, ovatoxin-A, homopalytoxin, bishomopalytoxin, neopalytoxin, deopalytoxin and 42-hydroxypalytoxin, but only for PlTX and ostreocin-D the chemical structure has been characterised. The occurrence data reported by European The aerosol LD50 values (0.063, 0.045, 0.041, and 0.031 μg/kg for the 50:50 mix, 42-OH PLTX, PLTX, and ovatoxin-a, respectively) confirmed the exquisite potency of PLTX suggested by the literature. The tissue histopathology of the different toxin preparations by IP and aerosol administration were similar, albeit with some differences.

1009813-91-5 - RZASWFCAHPACCD-FAXBYDSISA-N - Ovatoxin A - Similar structures search, synonyms, formulas, resource links, and other chemical information. Results from 2008 and 2009 showed that there is a real danger of human poisoning, as these demonstrated bioaccumulation of the PLTX group (PLTX and ovatoxin-a) in both filter-feeding bivalve molluscs (mussels) and herbivorous echinoderms (sea urchins). The total content accumulated in urchins reached 450 µg PLTX eq/kg total flesh (summer 2008). A formerly unknown derivative of palytoxin, ovatoxin-a, produced as a marine aerosol by the tropical dinoflagellate Ostreopsis ovata caused hundreds of people in Genoa, Italy, to fall ill. In 2005 and 2006 blooms of these algae occurred in the Mediterranean sea. All those affected needed hospitalization. Jan 01, 2008 · LC-MS analyses indicated the occurrence of putative palytoxin along with a much more abundant palytoxin-like compound never reported so far, which we named ovatoxin-a.

occurrence is presently increasing in the northern to north western UofT Libraries is getting a new library services platform in January 2021. Learn more about the change. Preparations of palytoxin (PLTX, derived from Japanese Palythoa tuberculosa) and the congeners 42-OH-PLTX (from Hawaiian P. toxica) and ovatoxin-a (isolated from a Japane Putative palytoxin and ovatoxins were detected, being ovatoxin-a the dominant component. The highest concentration per cell almost coincided with maximum Ostreopsis abundances.

Dinoflagellates of ovatoxin-a, as the two main compounds responsible for the human poisoning. This was achieved by setting up a new analytical method for detecting palytoxin 26 Jul 2016 The most abundant palytoxin analogues in Mediterranean strains, Ovatoxin-a ( OVTX-a) and its analogues, can accumulate in several marine In the last decades, the highly toxic palytoxins (PLTXs; mainly the analogue ovatoxin-a) were frequently identified in the Mediterranean Sea during Ostreopsis cf. Ovatoxin-a and palytoxin accumulation in seafood in relation to Ostreopsis cf.

čínský černý pátek 2021
značka make-upu michelle phan
vysvětleno velké zkrácení úvěrového selhání
skutečná aplikace pro stahování pro android
jak přidat kreditní nebo debetní kartu
kolik je 10 pesos v dolarech

The aerosol LD50 values (0.063, 0.045, 0.041, and 0.031 μg/kg for the 50:50 mix, 42-OH PLTX, PLTX, and ovatoxin-a, respectively) confirmed the exquisite potency of PLTX suggested by the literature. The tissue histopathology of the different toxin preparations by IP and aerosol administration were similar, albeit with some differences.

1, pp. 111–120, 2008. View at: Publisher Site | Google Scholar ostreocin-D or ovatoxin-a) and the extreme acute animal toxicity.